Abstract
Cytokines CCL11 (eotaxin) and HMGB1 (alarmin 1) are molecular markers of ageing and neurological, cardiovascular, and immune diseases. Created at the St. Petersburg Institute of Bioregulation and Gerontology, these short peptides are known to regulate gene expression and protein synthesis. They promote decreased mortality and deceleration of pathology in the elderly. The review suggests that the dipeptide vilon (Lys-Glu) and tetrapeptide epitalon (Ala-Glu-Asp-Gly) are involved in regulation of the CCL11 and HMGB1 genes as activators of their expression. The geroprotective effect of vilon and epitalon is probably due to the suppression of these genes.
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