Abstract
The occurrence and distribution of nerves displaying substance P-like immunoreactivity were investigated in the male and female genito-urinary tract of the guinea-pig, cat and rat. Substance P containing nerve fibers were comparatively more frequent in the guinea-pig than in the cat; they were absent in the rat. Immunoreactive nerve fibers were regularly found in the guinea-pig ureter, the trigonum area of the bladder, the vas deferens and the vagina. Here, the nerves were found in smooth muscle and around blood vessels; occasionally they were also seen just beneath the epithelium. Substance P containing nerves were very scarce in the other locations examined. The distribution of the substance P containing nerve fibers differed from that of adrenergic, cholinergic and vasoactive intestinal polypeptide containing nerves, indicating that the nerves containing substance P form a distinct system.
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