Peptidergic modulation of cerebellar nuclear neurons in promoting motor coordination

Abstract

Event Abstract Back to Event Peptidergic modulation of cerebellar nuclear neurons in promoting motor coordination Jing-Ning Zhu1* and Jian-Jun Wang1* 1 Nanjing University, State Key Laboratory of Pharmaceutical Biotechnology and Department of Biological Science and Technology, School of Life Sciences, China The cerebellar circuitry receives not only classic glutamatergic mossy fibers and climbing fibers but also fibers containing various peptides, such as orexin and corticotropin-releasing factor (CRF). Both the orexinergic afferent inputs from the hypothalamus and the CRFergic climbing fiber-like afferent inputs from the inferior olive directly excite projection neurons rather than interneurons in the cerebellar interposed nucleus (IN), one of the final outputs of the spinocerebellum. In addition, orexin receptors and CRF receptors are selectively expressed on projection neurons in the IN. Na+-Ca2+ exchangers and inward rectifier K+ channels co-mediate the orexin-induced inward currents on IN projection neurons, whereas HCN channels and inward rectifier K+ channels contribute to the excitation induced by CRF. Furthermore, microinjection of orexin or CRF into bilateral cerebellar INs significantly promotes motor balance and coordination. Intriguingly, blocking orexinergic afferent inputs in IN does not influence routine movements but remarkably attenuates motor performances during motor challenges, whereas interfering CRFergic climbing fiber-like inputs directly leads to an ataxia-like motor incoordination. Therefore, through direct modulations on cerebellar nuclear projection neurons, peptidergic inputs may play important roles in the cerebellar circuitry, and actively promote cerebellar motor control. Acknowledgements Supported by NSFC grants 31330033, 91332124, 31471112, 31461163001, and SRFDP/RGC ERG grant 20130091140003. Keywords: Cerebellar circuitry, Cerebellar nucleus, CRF, orexin, motor control Conference: 14th Meeting of the Asian-Pacific Society for Neurochemistry, Kuala Lumpur, Malaysia, 27 Aug - 30 Aug, 2016. Presentation Type: Symposium 1: Motor Control and Sensorimotor Integration: Circuitry and Plasticity Topic: 14th Meeting of the Asian-Pacific Society for Neurochemistry Citation: Zhu J and Wang J (2016). Peptidergic modulation of cerebellar nuclear neurons in promoting motor coordination. Conference Abstract: 14th Meeting of the Asian-Pacific Society for Neurochemistry. doi: 10.3389/conf.fncel.2016.36.00005 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 26 Jul 2016; Published Online: 11 Aug 2016. * Correspondence: Prof. Jing-Ning Zhu, Nanjing University, State Key Laboratory of Pharmaceutical Biotechnology and Department of Biological Science and Technology, School of Life Sciences, Nanjing, Jiangsu, China, jnzhu@nju.edu.cn Prof. Jian-Jun Wang, Nanjing University, State Key Laboratory of Pharmaceutical Biotechnology and Department of Biological Science and Technology, School of Life Sciences, Nanjing, Jiangsu, China, jjwang@nju.edu.cn Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Jing-Ning Zhu Jian-Jun Wang Google Jing-Ning Zhu Jian-Jun Wang Google Scholar Jing-Ning Zhu Jian-Jun Wang PubMed Jing-Ning Zhu Jian-Jun Wang Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.