Abstract
Peptide YY (PYY) was initially isolated from an ex tract of400 kg ofporcine duodenum using a novel chem ical assay that recognizes peptides with amidated car boxyl termini (Tatemoto and Mutt, 1981; Tatemoto, 1982). This latter structural modification is a characteris tic ofmany biologically active brain-gut peptides. Amino acid sequencing of the final purified product demon strated that peptide YY is a 36 amino acid residue pep tide that exhibits structural homology(Floyd et a!., 1976; Tatemoto et a!., 1982) to two other brain-gut peptides: pancreatic polypeptide (PP) and neuropeptide Y (NPY). These three peptides constitute the third family of struc turally related peptides to be isolated from the brain-gut axis. (This family is discussed further in this issue by Price and Greenberg.)
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