Abstract
Peptides P2122 (CKNNNSTNSGI) and P513 (CSQRSTNSAST) containing an epitope of a malarial surface antigen (MSA2) recognised by inhibitory monoclonal antibodies were conjugated to diphtheria toxoid (DT) protein and formulated with various gel-based and water in oil emulsion adjuvants in vaccine trials in mice and rabbits. The P2122-DT construct was effective in raising antibodies reactive with both the immunising peptide and the native antigen. Effective adjuvanticity as measured by the titre of the anti-peptide or anti-protein response in mice varied in the order: Algammulin, Montanide ISA 50 ≥ Freund's adjuvant, Montanide ISA 708, 721, 70 > > alum, Squalene Arlacel > SAF-1. A similar order of adjuvant efficacy: Freund's > alum > Squalene Arlacel > SAF-1, was observed in rabbits.
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