Abstract
Multimerization of peptide structures has been a logical evolution in their development as potential therapeutic molecules. The multivalent properties of these assemblies have attracted much attention from researchers in the past and the development of more complex branching dendrimeric structures, with a wide array of biocompatible building blocks is revealing previously unseen properties and activities. These branching multimer and dendrimer structures can induce greater effect on cellular targets than monomeric forms and act as potent antimicrobials, potential vaccine alternatives and promising candidates in biomedical imaging and drug delivery applications. This review aims to outline the chemical synthetic innovations for the development of these highly complex structures and highlight the extensive capabilities of these molecules to rival those of natural biomolecules.
Highlights
Given the advanced development and application multimerization, in this review, we summarise the recent development of peptide-based of peptide multimerization, review, we recent development of pepmultimerization therapeuticsinasthis inspiration forsummarise future drugthe development
An excellent review by Skwarczynski and Toth even gave insights into future of these structures such as the utilization of peptide-based synthetic vaccines, which can be chemically synthesised and could potentially mitigate a number of the disadvantages of traditional vaccines [46]. They further outline an exciting perspective of multimerized peptides for specific targeting, the introduction of modifications such as stapling, adjuvant usage and novel delivery systems for the therapeutic potential into the gastrointestinal tract (GT)
Peptide vaccines have been considered as a potential contender to mitigate these issues and the future of these molecules will be closely watched as the world contends with future pandemics
Summary
Advances in the development and utilization of biocompatible chemistries and methodologies can enable even an inexperienced bio/chemist to construct complex multimeric structures [9]. The utility 16 of peptides as potential therapeutics has increased, as shown by the significant rate of FDAapproved peptide drugs [19]. Peptidic drugs have widely acknowledged chaltherapeutics has increased, as shown theplasma significant rate negligible of FDA-approved peptide lenges and limitations because of theirby short half-life, oral bioavailabildrugs [19]. An arsenal of tools to build and tailor these structures increasing complexity and into effiThese multimerized structures can target specific tissuesofand receptors, deliver drugs can target specific tissues and environment receptors, deliver aciency. Tide-based multimerization therapeutics as inspiration for future drug development
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