Abstract
Recently, the isolation of new health-related bioactive molecules derived from agro-food industrial by-products by means of environment-friendly extraction processes has become of particular interest. In the present study, a protein by-product from the rice starch industry was hydrolysed with five commercial proteolytic enzymes, avoiding the use of solvents or chemicals. The digestion processes were optimised, and the digestates were separated in fractions with four different molecular weight ranges by using a cross-flow membrane filtration technique. Total hydrolysates and fractions were tested in vitro for a wide range of biological activities. For the first time rice-derived peptides were assayed for anti-tyrosinase, anti-inflammatory, cytotoxicity and irritation capacities. Antioxidant and anti-hypertensive activities were also evaluated. Protamex, Alcalase and Neutrase treatments produced peptide fractions with valuable bioactivities without resulting cytotoxic or irritant. Highest levels of bioactivity were detected in Protamex-derived samples, followed by samples treated with Alcalase. Based on the present results, a future direct exploitation of isolated peptide fractions in the nutraceutical, functional food and cosmetic industrial fields may be foreseen.
Highlights
The scientific community has become increasingly interested in the valorisation of industrial by-products, with the double aim of reducing waste volume and of recovering added value products
Of particular importance is the re-cycling and valorisation of agro-food industrial by-products as feedstocks for the isolation of bioactive molecules that could be exploited in the nutraceutical, functional food and cosmetic markets, all rapidly evolving sectors always in need of developing new classes of products
Bioactive Peptide Fractions from Rice By-Products the form of salaries for authors [FG] and [ML], and actively took part in the research activities in the frame of the BIORICE project but did not have any role in the study design and decision to publish
Summary
The scientific community has become increasingly interested in the valorisation of industrial by-products, with the double aim of reducing waste volume and of recovering added value products. Of particular importance is the re-cycling and valorisation of agro-food industrial by-products as feedstocks for the isolation of bioactive molecules that could be exploited in the nutraceutical, functional food and cosmetic markets, all rapidly evolving sectors always in need of developing new classes of products. Bioactive Peptide Fractions from Rice By-Products the form of salaries for authors [FG] and [ML], and actively took part in the research activities in the frame of the BIORICE project but did not have any role in the study design and decision to publish. The specific roles of these authors are articulated in the ‘author contributions’ section
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