Abstract
We investigated the release behavior of glucagon-like peptide-1 (GLP-1) from a biodegradable injectable polymer (IP) hydrogel. This hydrogel shows temperature-responsive irreversible gelation due to the covalent bond formation through a thiol-ene reaction. In vitro sustained release of GLP-1 from an irreversible IP formulation (F(P1/D+PA40)) was observed compared with a reversible (physical gelation) IP formulation (F(P1)). Moreover, pharmaceutically active levels of GLP-1 were maintained in blood after subcutaneous injection of the irreversible IP formulation into rats. This system should be useful for the minimally invasive sustained drug release of peptide drugs and other water-soluble bioactive reagents.
Highlights
Various temperature-responsive water-soluble polymers have been investigated for application in drug delivery systems (DDSs) [1,2,3,4,5,6,7,8,9]
We evaluated using temperature-triggered covalent gelation system. We evaluated this injectable polymer (IP) system as this IP system as a sustained peptide drug release device by studying the release behavior of a peptide a sustained peptide drug release device by studying the release behavior of a peptide from hydrogels from hydrogels prepared using our IP system
We investigated the in vitro release behavior of glucagon-like peptide-1 (GLP-1) from the formulations
Summary
Various temperature-responsive water-soluble polymers have been investigated for application in drug delivery systems (DDSs) [1,2,3,4,5,6,7,8,9]. Several polymers in aqueous solution exhibit a temperatureresponsive sol-to-gel transition between room temperature (r.t.) and body temperature and can be used as injectable polymer (IP) systems. Such polymer solutions can be mixed with water-soluble bioactive reagents such as proteins, peptides, or living cells before injection, and form a hydrogel entrapping these reagents at the injection site in the body. Temperature-responsive biodegradable IP hydrogels, once formed in the body, are likely to quickly revert to the sol state (typically in less than 24 h) at the injection site, where there is a large amount of body fluid [14]
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