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Abstract
The trimethylsilylethyl ester group was used as an orthogonal protecting group to perform an on-resin cyclization of a peptide prepared by conventional Fmoc protection strategy. Fmoc-Asp(OTMSE)OH was prepared, incorporated into a peptide, deprotected in the presence of fluoride, cyclized in the presence of BOP, and cleaved from the resin to afford directly a head-to-sidechain cyclic peptide.
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