Abstract
AbstractThe biofunctional significance of hollow mesoporous silica nanoparticles (HMSNs) could be used as nano‐reservoirs. Here in the β‐sitosterol loaded into the hollow core and the cisplatin substituted with the carboxylic group of poly lactic acid (PLA)‐ polyethylene glycol (PEG) on the pore walls of HMSNs. Subsequently, the tumour biomarker somatostatin peptide (3207‐86) conjugated to Methyl polyethylene glycol 2‐maleimide ethyl ether (Meo‐PEG‐Mal) for the selective targeting of tumour cells. The surface modified HMSNs enable the internalization of cisplatin via chlorine ion release, through the cleavage of the coordinated interaction. Further, the β sitosterol release is dependent on the discharge rate of cisplatin and the pH of the cell microenvironment. The engineered nano‐drug delivery system could be used to selectively target cancer cells and deliver multimodal therapeutic schemes for the treatment of colon cancer
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