Abstract
BackgroundThe overall survival rate of osteosarcoma (OS) patients has not been improved for 30 years, and the diagnosis and treatment of OS is still a critical issue. To improve OS treatment and prognosis, novel kinds of theranostic modalities are required. Molecular optical imaging and phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT), are promising strategies for cancer theranostics that exhibit high imaging sensitivity as well as favorable therapeutic efficacy with minimal side effect. In this study, semiconducting polymer nanoparticles (SPN-PT) for OS-targeted PTT/PDT are designed and prepared, using a semiconducting polymer (PCPDTBT), providing fluorescent emission in the second near-infrared window (NIR-II, 1000 - 1700 nm) and photoacoustic (PA) signal in the first near-infrared window (NIR-I, 650 - 900 nm), served as the photosensitizer, and a polyethylene glycolylated (PEGylated) peptide PT, providing targeting ability to OS.ResultsThe results showed that SPN-PT nanoparticles significantly accelerated OS-specific cellular uptake and enhanced therapeutic efficiency of PTT and PDT effects in OS cell lines and xenograft mouse models. SPN-PT carried out significant anti-tumor activities against OS both in vitro and in vivo.ConclusionsPeptide-based semiconducting polymer nanoparticles permit efficient NIR-II fluorescence/NIR-I PA dual-modal imaging and targeted PTT/PDT for OS.Graphic
Highlights
Osteosarcoma (OS) is the most common malignant and aggressive primary bone tumor that affects children and adolescents, which is locally destructive and highly metastatic [1, 2]
semiconducting polymer nanoparticles (SPN-PT) and its counterpart Semiconducting polymer nanoparticles (SPNs)-SP were prepared via a nanoprecipitation method which used PEG-PT or PEG-SP, respectively, to encapsulate hydrophobic semiconducting polymer PCPDTBT
The diameters of SPN-PT decreased in fetal bovine serum (FBS) compared to those in phosphate buffer solution (PBS) or MEM, the possible reason is that the degree of dispersion of SPN-PT may be changed by the biological proteins in FBS
Summary
Osteosarcoma (OS) is the most common malignant and aggressive primary bone tumor that affects children and adolescents, which is locally destructive and highly metastatic [1, 2]. Combined regimens of poly-chemotherapy and surgical removal of the primary tumor along with all clinically evident metastatic disease remain major management strategies for OS patients [3,4,5]. A theranostic method equipped with good sensitivity, high targeting ability and therapeutic efficiency for OS is urgently need. The overall survival rate of osteosarcoma (OS) patients has not been improved for 30 years, and the diagnosis and treatment of OS is still a critical issue. Molecular optical imaging and phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT), are promising strategies for cancer theranostics that exhibit high imaging sensitivity as well as favorable therapeutic efficacy with minimal side effect. In this study, semiconducting polymer nanoparticles (SPN-PT) for OS-targeted PTT/PDT are designed and prepared, using a semiconducting polymer (PCPDTBT), providing fluorescent emission in the second near-infrared window (NIR-II, 1000 - 1700 nm) and photoacoustic (PA) signal in the first near-infrared window (NIR-I, 650 - 900 nm), served as the photosensitizer, and a polyethylene glycolylated (PEGylated) peptide PT, providing targeting ability to OS
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