Abstract
Background: Reflux is a common clinical complaint within the UK and USA population, often causing troublesome symptoms for example, heartburn, regurgitation and hoarseness. These symptoms are commonly associated with gastroesophageal reflux disease (GERD) and laryngopharyngeal reflux (LPR). Procedures for diagnosing reflux are at present invasive, time consuming and in some cases not reliable, leading to many individuals seeking a quick and easy non-invasive diagnostic method for self-diagnosis. It has been shown that pepsin detection within a sputum and/or saliva sample is a sensitive, non-invasive diagnostic method for proximal reflux of gastric contents. Using pepsin as a biomarker for reflux led to the development of Peptest, which is a non-invasive, rapid diagnostic procedure used to identify pepsin within a saliva sample. The aim of this study was to show how pepsin can be used as a biomarker for reflux, using Peptest for the self-diagnosis of reflux related symptoms.
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