Abstract
The chronic administration of ethanol in large amounts to rats gives rise to an increasing degree of withdrawal hyperexcitability as demonstrated by reduction in the seizure threshold to the convulsant drug pentylenetetrazol. The latter response is reasonably specific and is a more sensitive measure of physical dependence in rats than the changes in behavior or susceptibility to audiogenic seizures. The results in total indicate that the induction of physical dependence of ethanol in rats can be objectively and quantitatively followed by assessing the intensity of withdrawal hyperexcitability with pentylenetetrazol.
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