Abstract
OBJECTIVES:Progressive renal disease is characterized by histological changes in the kidney and fibrosis is a common outcome. Renal biopsy is the only diagnostic tool to evaluate these histopathological changes. Pentraxin-2 (PTX-2) is an anti-inflammatory constitutive plasma protein associated with the innate immune system. Recently, as a biomarker, the circulating level of PTX-2 is shown to be decreased in chronic fibrotic diseases. In this study, we aimed to investigate the relationship between renal fibrosis severity and serum PTX-2 levels in patients undergoing renal biopsy.METHODS:This cross-sectional study included 45 patients and 16 healthy individuals (HIs). The severity of renal fibrosis was evaluated according to the Banff and Sethi scoring systems by the same pathologist. PTX-2 was measured by an enzyme-linked immunosorbent assay and compared with the demographical, clinical, biochemical, and histopathological data of the patients and HIs.RESULTS:PTX-2 levels were lower in the biopsy group than in the HI group (p=0.12). Patients with moderate renal fibrosis had significantly lower serum PTX-2 levels than those in patients with minimal and mild fibrosis (p=0.017 and p=0.010, respectively). PTX-2 concentrations were correlated with serum albumin (r=0.30, p=0.016), and were negatively correlated with serum creatinine levels (rho=-0.42, p=0.01) and body mass index (r=-0.32, p=0.011).CONCLUSIONS:The results indicated that PTX-2 levels are significantly lower in patients with renal fibrosis than HIs, and declining further in patients with severe fibrosis.
Highlights
Chronic kidney disease (CKD) has been a growing healthcare problem with increasing prevalence
The renal parenchyma loses its function because of the immoderate deposition of extracellular matrix components, resulting in renal fibrosis. This kind of fibrosis can affect all histological components of the kidney; it is termed as arteriosclerosis/perivascular fibrosis in the vasculature, interstitial fibrosis in the tubulointerstitium, and glomerulosclerosis in the glomeruli
PTX-2 increases the migration of immune-regulatory macrophages, suppresses the differentiation of monocytederived fibroblast-like cells, and inhibits neutrophil adhesion to extracellular matrix proteins [3]
Summary
Chronic kidney disease (CKD) has been a growing healthcare problem with increasing prevalence. More than 10% of the population in developed countries is considered to have CKD, with a variety of etiologies such as hypertension, diabetes, glomerulonephritis, and so on [1]. The renal parenchyma loses its function because of the immoderate deposition of extracellular matrix components, resulting in renal fibrosis. This kind of fibrosis can affect all histological components of the kidney; it is termed as arteriosclerosis/perivascular fibrosis in the vasculature, interstitial fibrosis in the tubulointerstitium, and glomerulosclerosis in the glomeruli. Received for publication on June 8, 2020. Accepted for publication on Jun 30, 2020
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