Pentraxin 3 Levels in Young Women with and without Polycystic Ovary Syndrome (PCOS) in relation to the Nutritional Status and Systemic Inflammation.

Katarzyna Wyskida,Piotr Choręza,Grzegorz Franik,Paweł Madej,Leszek Markuszewski,Aleksander Owczarek,Magdalena Olszanecka-Glinianowicz,Jerzy Chudek,Natalia Pohl

doi:10.1155/2020/1380176

Katarzyna Wyskida, Piotr Choręza + Show 7 more

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https://doi.org/10.1155/2020/1380176

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Abstract

Objective The aim of the study was to assess PTX3 levels in PCOS and non-PCOS women in relation to nutritional status and circulating markers of inflammation. Methods The study enrolled 99 stable body mass PCOS women (17 normal weight, 21 overweight, and 61 obese) and 61 non-PCOS women (24 normal weight, 19 overweight, and 18 obese). Body composition was assessed by bioimpedance, and plasma levels of pentraxin 3 (PTX3), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and monocyte chemoattractant protein 1 (MCP-1) were measured. Homeostatic model assessment of insulin resistance (HOMA-IR) was made. Results Plasma PTX3, TNF-α, and IL-6 levels and HOMA-IR were higher in PCOS than in non-PCOS group (p < 0.001). There were positive correlations between log10 (PTX3) and log10 (BMI), waist circumference and fat percentage, as well as log10 (HOMA-IR) and free androgen index but negative between log10 (estradiol) levels in PCOS. While in the non-PCOS group, the correlations between log10 (PTX3) and log10 (BMI), waist circumference and fat percentage, as well as log10 (HOMA-IR) were negative. The positive correlations between PTX3 and MPC-1 and log10 (IL-6) were shown in the PCOS group only. In multivariate regression analyses, variability in PTX3 levels in the PCOS group was proportional to log10 (BMI), waist circumference, and fat percentage, but inversely proportional to log10 (estradiol) levels. While in the non-PCOS group, PTX3 levels were inversely proportional to all anthropometric parameters. Conclusions Our results show that the decrease in PTX3 levels observed in obese is distorted in PCOS by microinflammation, and possibly, dysfunction of stroma adipose tissue and liver steatosis is reflected by enhanced insulin resistance.

Highlights

IntroductionE aim of the study was to assess pentraxin 3 (PTX3) levels in PCOS and non-PCOS women in relation to nutritional status and circulating markers of inflammation
Katarzyna Wyskida,1 Grzegorz Franik,2 Piotr Choreza,3 Natalia Pohl,3 Leszek Markuszewski,4 Aleksander Owczarek,5 Paweł Madej,2 Jerzy Chudek,5,6 and Magdalena Olszanecka-Glinianowicz 1
Our results show that the decrease in pentraxin 3 (PTX3) levels observed in obese is distorted in PCOS by microinflammation, and possibly, dysfunction of stroma adipose tissue and liver steatosis is reflected by enhanced insulin resistance

Summary

Introduction

E aim of the study was to assess PTX3 levels in PCOS and non-PCOS women in relation to nutritional status and circulating markers of inflammation. Plasma PTX3, TNF-α, and IL-6 levels and HOMA-IR were higher in PCOS than in non-PCOS group (p < 0.001). While in the non-PCOS group, the correlations between log (PTX3) and log (BMI), waist circumference and fat percentage, as well as log (HOMA-IR) were negative. The results of studies assessed circulating PTX3 levels in PCOS women are inconsistent [9,10,11,12,13], and its associations with nutritional status and insulin resistance are unclear [14,15,16]. Only one study assessed the association between PTX3 and TNF-α and IL-6 levels. is study revealed a positive correlation between these parameters in morbidly obese subjects [17]

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