Pentraxin 3 Increase is Much Less Pronounced Than C-Reactive Protein Increase After Surgical Procedures

Abstract

Pentraxin 3 is an acute phase marker that belongs to the same protein family as C-reactive protein (CRP). The aim of this study was to compare the acute phase reactions of pentraxin 3 and CRP in humans. High sensitivity CRP and pentraxin 3 were analyzed in blood samples from orthopedic surgery (n = 29) and coronary bypass patients (n = 21). The samples were collected prior to surgery and 4 and 30days after surgery, respectively. Both CRP and pentraxin 3 were significantly increased at day4. Median pentraxin 3 values increased from 4,021 to 7,459pg/mL in the orthopedic group and from 4,637pg/mL to 10,419pg/mL in the coronary bypass group while CRP increased from 6.3mg/L to 151.6mg/L and from 5.7mg/L to 176.3mg/L in the same groups. Pentraxin 3 shows a much smaller increment in humans in comparison with CRP.