Abstract
Introduction: Pentoxifylline (PTX) is a methylxanthine derivative that inhibits phosphodiesterase activity, induces vasodilation, and blocks the effect of TNF-α. Currently, PTX is a commonly used drug for tissue ischemia and other inflammatory conditions. Although its immunomudulation property has been recognized, the effect of PTX on dendritic cells (DCs), the most efficient antigen-presenting cells, is unknown. The present work aimed at determining whether PTX could suppress DC differentiation, maturation, and its associated functions.
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