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Abstract
We treated 34 radiation-induced superficial fibrotic lesions with pentoxifylline and vitamin E for 3 months. Mean surface area of the lesions decreased from 112 to 65 cm 2 after treatment ( P<0.001). A subgroup of 21 fibrotic lesions received the medications for 6 months, in which surface area decreased from 80 to 27 cm 2 ( P<0.001). Pentoxifylline–vitamin E combination improved radiation-induced fibrosis.
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