Abstract
Developmental differences in pentobarbital-activated Cl − currents were studied in adult and embryonic human dorsal root ganglia (DRG) neurons using whole-cell patch-clamp recordings. Pentobarbital-induced Cl − conductance was significantly greater in adult DRGs (28.4 pS) than in embryonic cells (19.1 pS). Fluctuation analysis of the spectral density plots of Cl − channel activation by pentobarbital showed age differences in the length and number of open time constants (adult cells, τ 1 , τ 2, τ 3 were 224, 8.4, 1.5 ms, respectively; embryonic cells τ 1 and τ 2 were 165 and 26.3 ms, respectively). The different kinetic properties of human adult and embryonic DRG Cl − channels opened by pentobarbital may reflect the presence of different subunits in the two populations of neurons.
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