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Abstract
In the rat, pentazocine produces a dose-dependent increase in the threshold for vocalisation and vocalisation afterdischarge (affective component of teh pain reactions); the threshold for a motor response is unchanged. Inhibition of tyrosine hydroxylase, dopamine β-hydroxylase or pretreatment with 1-Dopa showed that an increased dopamine concentration and a decreased noradrenaline concentration antagonized the antinociceptive actions of pentazocine. After inhibition of tyrosine hydroxylase or dopamine β-hydroxylase, pentazocine accelerated the depletion of noradrenaline and dopamine. The most pronounced effect was found on dopamine in regions including the diencephalon-mesencephalon. It is suggested that the pentazocine-induced increases of the threshold for vocalisation and vocalisation afterdischarge are related to a blockade of dopamine receptors and an increased turnover of noradrenaline.
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