Abstract
The mechanism of activation of hepatic microsomal glucose-6-phosphatase (EC 3.1.3.9) in vitro by pentamidine has been investigated in both intact and fully disrupted microsomes. The major effect of pentamidine is a 4.7-fold reduction in the K m of glucose-6-phosphatase activity in intact diabetic rat liver microsomes. The site of action of pentamidine is T 1 the hepatic microsomal glucose 6-phosphate transport protein. The activation of T 1 by pentamidine may contribute to the disturbed blood glucose homeostasis see in many patients after administration of the drug pentamidine.
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