Abstract
A simple, inexpensive, environmentally friendly, and efficient route for the synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives via the one-pot three-component Biginelli reaction using pentafluorophenylammonium triflate (PFPAT) as a catalyst is described. The organocatalyst is air-stable, cost-effective, easy to handle, and easily removed from the reaction mixtures.
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