Abstract
1. Two methods were developed for the synthesis of (pentafluorobenzoyl)acetic ester: by the condensation of pentafluorobenzoyl chloride with the ethoxymagnesium derivative of malonic ester with subsequent partial hydrolysis and decarboxylation, and by the ester condensation of ethyl pentafluorobenzoate with ethyl acetate in presence of bromo(diisopropylamino)magnesium. 2. In the condensation of ethyl pentafluorobenzoate with sodioacetoacetic ester, as a result of nucleophilic substitution and subsequent hydrolysis, diethyl tetrafluorohomoterephthalate is formed. By the hydrolysis of the latter with partial decarboxylation, (2,3,5,6-tetrafluorophenyl)acetate acid was obtained.
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Schedule a callMore From: Bulletin of the Academy of Sciences, USSR Division of Chemical Science
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