Abstract
The aim of this study was to synthesize and evaluate physicochemical properties of a new salicylate derivative in experimental calcium-based root canal sealers. Two salicylate derivatives were synthesized for the transesterification reaction of methyl salicylate with two different alcohols (1,3-butylenoglicol disalicylate-BD and pentaerythritol tetrasalicylate -PT) in molar ratio 1:3 and 1:6, respectively. The products (BD and PT), were characterized by Fourier Transform Infrared Spectroscopy (FTIR) and Nuclear Magnetic Resonance spectroscopy (RMN). Calcium-based experimental sealers were prepared with the same catalyst paste (60% of MTA, 39% of n-ethyl-o-toluenesulfonamide, and 1% titanium dioxide) and four different concentrations of BD and PT in the base pastes (40/0 - control, 35/5, 30/10 and 20/20) with 60% of bismuth oxide. The experimental sealers were evaluated for setting time, solubility (24 h, 7, 14 and 30 days), diametral tensile strength and Young's Modulus. Data were analyzed by one- or two-way ANOVA with Tukey's test (p<0.05). The addition of PT reduced the materials setting time. After 24 h the sealer 40/0 and 35/5 had higher solubility, and after 14 and 28 days the sealer 20/20 showed the lowest solubility (p<0.05). After 7 days the sealer 20/20 stabilized its solubility. The sealer 40/0 presented the highest values and the 20/20 presented the lowest values of diametral tensile strength and Young's modulus (p<0.05). The addition of PT to calcium-based root canal sealers provides benefits to the setting time and solubility.
Highlights
Different techniques can be used for endodontic filling, and most them use gutta-percha points associated with endodontic sealers
The aim of this study was to synthesize a new salicylate derivative (PT) and evaluate physicochemical properties of experimental calcium-based root canal sealers made with this salicylate derivative
Synthesis of Salicylate Derivatives Two salicylate derivatives were synthesized by transesterification of methyl salicylate (Synth Laboratory, São Paulo, SP, Brazil) with two different alcohols, butylenoglicol disalicylate (BD) and pentaerythritol tetrasalicylate (PT), in a molar ratio of 1:3 and 1:6, respectively (Fig. 1)
Summary
Different techniques can be used for endodontic filling, and most them use gutta-percha points associated with endodontic sealers. Many types of root canal sealers are available in the market with different physicochemical and biological properties [1,2]. Special attention has been given to calcium hydroxide-based sealers and its action mechanism, which promotes periapical tissue repair. Due to their biological properties, this type of root sealer is capable to release calcium ions and hydroxyls that increase the pH [4,5,6,7,8] and induces the repair of the affected area through the neo-tissue formation [9]. The advantage of replacing the calcium hydroxide by MTA is the possibility to control or, at least, to reduce the excessive solubility of currents sealers without loss the desirable biological properties [13]
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