Abstract
Heterotopic ossification (HO) is a condition that can occur as a result of tissue trauma, characterized by mature bone formation outside of anatomic bone. In this study we investigated the effect of stable gastric pentadecapeptide BPC 157 on heterotopic ossification in rats. A mature bone and bone marrow cylinder was implanted in the quadriceps muscle of the hind leg. BPC 157 treated rats received BPC 157 (10 μg/kg) dissolved in drinking water (0.16 μg/ml/12ml/day) till sacrifice (1‐4 weeks). Rats in control group received only drinking water. Throughout the duration of the experiment we conducted functional measurements (MFI‐ modified motor function index, shortening of the leg). After sacrifice X ray examination was performed on the donor site and on the locus of the induced HO. Formation of heterotopic bone was reduced on radiographs, the experimental fractures healed better and the function of the leg was improved in BPC 157 treated group. The control group deteriorated in all of the before mentioned parameters. We can conclude that the pentadecapeptide BPC 157 induces both bone formation in fracture and heterotopic bone ossification absorption in rats.Grant Funding Source: Supported by Grant 108‐1083570‐3635, Ministry of Science, Education and Sports, Croatia
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