Abstract
The Celastraceae family comprises about 96 genera and more than 1.350 species, occurring mainly in tropical and subtropical regions of the world. The species of this family stand out as important plant sources of triterpenes, both in terms of abundance and structural diversity. Triterpenoids found in Celastraceae species display mainly lupane, ursane, oleanane, and friedelane skeletons, exhibiting a wide range of biological activities such as antiviral, antimicrobial, analgesic, anti-inflammatory, and cytotoxic against various tumor cell lines. This review aimed to document all triterpenes isolated from different botanical parts of species of the Celastraceae family covering 2001 to 2021. Furthermore, a compilation of their 13C-NMR data was carried out to help characterize compounds in future investigations. A total of 504 pentacyclic triterpenes were compiled and distinguished as 29 aromatic, 50 dimers, 103 friedelanes, 89 lupanes, 102 oleananes, 22 quinonemethides, 88 ursanes and 21 classified as others.
Highlights
The Celastraceae family comprises approximately 96 genera, reaching about 1350 species distributed in the tropical and subtropical regions of the world [1,2]
Considering the chemical composition, species of the Celastraceae family are rich in pentacyclic triterpenes (PCTTs)
This review aims to present the PCTTs reported for species of the Celastraceae family in the 21st century, exhibiting from which species they were isolated and contributing to the chTehmisirceavlicehwaraaicmtesrtiozaptiroensepnrtotcheessPCofTtThserseepcoormtepdofuonrdsps elicsiteisngofththeeirC13eClaNstMraRcedaeatfaa.mTihlye iinnftohrem2a1tsiot nceanbtuouryt,tehxehPibCitTinTgs wfroams owbthaiicnhedspferocimesStchieFyinwdeerre, Siscoolpautesd, aannddWcoenbtroibf uSctiinegncteo, tuhseincghemasicakl echyarasecaterrcihzattioernmpsr:oce“sCseolafstthreasceeaceomapnodundtrsitleisrtpinengetsh”e,ir 1“3CCelNasMtrRacdeaatea
Summary
The Celastraceae family comprises approximately 96 genera, reaching about 1350 species distributed in the tropical and subtropical regions of the world [1,2]. Quinonemethides are chemomarkers of this family are found exclusively in these species [13] These PCTTs can occur as alcohols, ketones, carboxylic acids, lactones, aldehydes, epoxides, esters, or even glycosylated derivatives. These PCTTs can be sub-classified as seco, generally due to the opening of one of their rings, the most common being the ring ‘A’ opening between carbons 3 and 4, and sub-classified as nor when there is a lack of any of the methyl groups that constitute the basic skeleton. FiguFfrrieogmu2r.eisSo2ip.mrSepimnleipfi. lDeifdiMedbAibPoiPso:ysydnnitmthheeettthiiccylrraoolluuytlteedoiofpfh22,o3s,−3po−hxaiodtexo;isdIqPouPsa:qleiusnoeap,leetnhnteee,ndtyihrleedctidppihrroeesccputhrpsaortere;coGuf PrtsrPiot:ergrpeorefannterysil,terpenes, fromdiipsohopsrpehnaet.e;DFPMP:AfaPrPne: sdyilmdiepthhoyslpahlalytel; dPPip: hdiopshpohspahtea;teIP[2P6,:2i8s]o. pentenyl diphosphate; GPP: geranyl diphosphate; FPP: farnesyl diphosphate; PP: diphosphate [26,28]
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