Abstract
This is an original research of penis allotransplantation. The paper presents an experiment allogenic penis transplantation model in Beagles, with a focus on recovery of blood supply and changes in tissue architecture. Twenty adult Beagles were allocated to 10 pairs for penile transplantation. After operation, the skin and glans were observed. If adverse symptoms occurred, the transplanted penis was resected and pathologically examined. Frequency of urination, urinary stream, and patency level were recorded 7 days after transplantation. Cystourethrography was performed on Day 10. The transplanted penises were resected on Day 14 for pathological examination. The research showed that transplanted penises survived after allotransplantation, and the dogs regained urination ability. Penis autotransplantation in Beagles is feasible. This preliminary study shows a potential for application of this new procedure for penis transplantation in humans.
Highlights
War injury, trauma, penis tumor surgery, and congenital diseases may be associated with partial or complete penile defect, which deprives men of the ability of urination while standing and sexual activity
Subcutaneous tissue, albuginea, and cavernous body could be clearly seen in the cross section of the penises
The advancement of several technologies including transplantation immunity, tissue typing and immunosuppressants, the high long-term survival rate of extremity allotransplantation in animals, and the high success rate of penis allotransplantation in the present study provides a solid ground for treating patients with penile defect using penis transplantation
Summary
Trauma, penis tumor surgery, and congenital diseases may be associated with partial or complete penile defect, which deprives men of the ability of urination while standing and sexual activity. This condition often causes mental and psychological trauma and induces a heavy emotional and psychological burden to the patients and their families. The main treatment methods for penis defects include phalloplasty with free flaps or pedicled flaps, penis lengthening, and penis reconstruction [1,2,3]. Replantation is not always possible and reconstruction is necessary
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