Abstract
Introduction of 13-valent pneumococcal conjugate vaccine in the United States was not associated with a significant change in prevalence of penicillin resistance in nonvaccine type serotypes because of the variable success of highly resistant serotypes. Differences in regional serotype distribution and serotype-specific resistance contributed to geographic heterogeneity of penicillin resistance.
Highlights
Introduction of 13-valent pneumococcal conjugate vaccine in the United States was not associated with a significant change in prevalence of penicillin resistance in nonvaccine type serotypes because of the variable success of highly resistant serotypes
Post-PCV7, this factor played a diminishing role in explaining geographic heterogeneity in penicillin resistance, with variation in serotype distribution between sites being of increasing importance [8]
We considered penicillin-nonsusceptible pneumococcus (PNSP) non-PCV13 serotypes detected in patients in all age groups from 2009 through 2012
Summary
The prevalence of penicillin-resistant pneumococcus strains varies considerably between states [7,8] Such variation might be caused by differences in serotype distribution (such that some locations have a higher prevalence of strains that are generally more resistant) or higher-than-average levels of resistance within serotypes. Post-PCV7, this factor played a diminishing role in explaining geographic heterogeneity in penicillin resistance, with variation in serotype distribution between sites being of increasing importance [8]. The Study To analyze NVT penicillin-nonsusceptible pneumococcus (PNSP) detected in patients with invasive pneumococcal disease, we used data from the Active Bacterial Core surveillance (ABCs) system, a population- and laboratory-based collaborative system between the Centers for Disease Control and Prevention and state health departments and academic institutions in 10 states (California, Colorado, Connecticut, Georgia, Maryland, Minnesota, New Mexico, New York, Oregon, and Tennessee). We calculated the Spearman correlation coefficient between the proportion of PNSP for each pair of serotypes across states in 2009 (range –0.09 to 0.66) and 2012 (range 0.30–0.79)
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