Abstract
Permeability of the placental barrier to penicillin was studied on pregnant rats on the 11th, 16th, and 20th days of pregnancy. The penicillin concentration was compared in the mother's blood and the fetal tissue fluids at various stages of pregnancy 30 min, 2 and 3 hr after its intramuscular administration in a dose of 20,000 units/kg body weight. The penicillin concentration was examined by Ermol'eva and Ved'mina's serial dilution micromethod. The placenta of white rats is permeable to penicillin on the 11th, 16th, and 20th days of pregnancy; it is more permeable on the 20th day than on the 11th and 16th days. The concentration of antibiotic in the mother's blood is higher than in the fetal tissues. A reduction of the blood penicillin level occurs in pregnant rats much more rapidly than in the fetus.
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