Abstract
A CIRCULATING antipenicillin antibody (CAPA) was first detected in the serum of blood donors who had previously taken penicillin.<sup>1</sup>Subsequently, several cases of hemolytic anemia were reported in patients receiving large doses of penicillin. These patients had CAPA and positive direct Coombs' tests.<sup>2-8</sup> This report describes an induced Coombs' —positive, immunohemolytic anemia with CAPA, characterized as 7S (γ-G-) globulin, in a patient receiving prophylactic penicillin. This case is compared with other similar cases and the condition of penicillin induced immunohemolytic anemia is discussed. <h3>Report of Case</h3> A 41-year-old white woman was admitted to Hahnemann Hospital for cardiac evaluation. She had had no drug reactions, allergies, or blood diseases. On examination, the blood pressure was 130/100 mm Hg with a sinus tachycardia, rate of 120 to 140/ minute. The impulse of the right ventricle was palpable. Auscultatory findings included a loud first heart sound and wide and relatively fixed
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