Abstract
With the advent of the sulfonamides the eradication of gonorrhea from the human race seemed quite likely. The promise contained in the earlier reports for the treatment of gonorrhea with sulfonamides, however, has not been completely fulfilled. Moreover, the therapeutic results for the female have not been so good as for the male, because of vagaries in her anatomic makeup. The physiologic mucoid alkaline secretions of the cervix aid and abet the growth of the gonococcus; the anatomic arbor-like arrangement of the cervical glands conceal this micro-organism in protective depots for survival. Even against such odds the sulfonamides brought under control a very large number of women with acute and chronic gonorrhea. The exceptions were the females who harbored resistant strains or in whom, because of chronicity of long duration, the gonococcus had taken tenacious hold in the subepithelial layers of the mucosa lining Skene's ducts, Bartholin's glands, the endocervix
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