Abstract
The effects of subMlCs of penicillin and clindamycin on group A streptococcal products were analyzed. Penicillin caused an increase in the expression of the group carbohydrate for the three strains tested; in contrast, clindamycin inhibited the expression in two strains. The M and T proteins were not affected by the drugs. Clindamycin caused an increase in the hyaluronidase activity and both antimicrobial agents inhibited the activity of streptolysin at 1/2 MIC.
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