Abstract
Hormonal pills and injection are popular contraceptive method in Indonesia, with a high number of dropout rate because of the side effects. Papaya seeds are considered to have antifertility compounds as alternative contraceptives with minimum side effect. This research aims to determine the effect of papaya seed ethanol extract on the amount of mucosal epithelial cell of falopiian tube in female white rats. This research was conducted in November 2019 – January 2020 using true experimental design with Random Post Test Only Control Group Design. The research sample use 32 female white rats, divided into 4 groups: control group (without papaya seed extract), group 1 (0,1mg/g BW), group 2 (0,2mg/g BW), and group 3 (0,3mg/g BW). The treatment was given for 20 days. After treatment, sample terminated in the pro estrus phase, then histopathological examination was performed with Hematoxylin-Eosin and observed with the Olympus Dot Slide Microscope BX 51 with 400x magnification using Olyvia Application. The result showed decreased the amount of fallopian tube mucosal epithelial cells in each group as the dose increased. Conclusion of this study was the papaya seed ethanol extract has effect to decrease the structure and amount of mucosal epithelial cells of the fallopian tube with optimal doses in group 3, but statistical analysis not shown a significant difference (p>0.05).
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