Abstract
Drugs used with foods or drinks can affect the drug effects. This study aims to observe the effect of papaya juice (Carica papaya L.) to the pharmacokinetics profile of cimetidine in white rats. The animal were randomly in three group. Group 1 (cimetidine) was given a single oral cimetidine 3,6 mg/200gBW. Group 2 (cimetidine and papaya juice dose I) was given cimetidine 3,6 mg/200gBW together with papaya juice 4,5 g /200gBW. Group 3 (cimetidine and papaya juice dose II) was given cimetidine 3,6 mg/200gBW together with papaya juice 9 g /200gBW. The serial blood was collected for 4 hours on lateralis vein of rats tail. Determination of cimetidine in plasma performed by spectrophotometer UV. The pharmacokinetic parameters of cimetidine were calculated by regresi linear method and recidual method and were analyzed by One Way ANOVA using 95 % confidence interval. Based on research results showed that the group II and group III increased of ka, Cpmaks, tmaks, Cl, AUC and decreased ke, t½ab and t½el. Group III provides the most affect the cimetidine pharmacokinetics profile with decreased absorption and elimination and increased metabolism of cimetidine in rat.
Highlights
Obat yang digunakan bersamaan dengan makanan atau minuman dapat mempengaruhi efek terapi obat tersebut
This study aims to observe the effect of papaya juice (Carica papaya L.) to the pharmacokinetics profile of cimetidine in white rats
Ulcer Disease: Incidence, Recurrence, Risk Factors and Mortalit
Summary
Bahan Bahan yang digunakan dalam penelitian ini adalah Aluminium foil, aquadest, etil asetat, kertas saring, metanol , simetidin baku standar, sanmetidin, jus buah pepaya (Carica papaya L.), EDTA 5%, dan Tricloroasetat acid (TCA) 5%. Peralatan Peralatan yang digunakan dalam penelitian ini adalah batang pengaduk dan sendok tanduk, beaker glass 50 mL dan 100 mL, corong kaca, cawan porselen, holder tikus, kaca arloji, labu takar 10 mL, labu takar 5 mL, labu takar 50 mL, kandang hewan uji, lemari pembeku (freezer), micropipet 100 dan 1000 μL (Hamilton), neraca analitik, oven, pencampur (vortex mixer), pemusing (sentrifuge), blender, pipet tetes, pipet ukur berbagai ukuran, pisau cukur (gilette), gunting biologis, plester, Spektrofotometer UV-Visible, spuit oral 1 mL dan 3 mL, mikrotube ependroff, tabung reaksi 3 mL dan 10 mL dan rak tabung reaksi. Hewan uji Hewan yang digunakan dalam penelitian ini adalah tikus putih jantan galur Wistar usia 2-3 bulan dengan berat antara 170-250 gram. Tiga kelompok tersebut yaitu kelompok simetidin dimana hewan uji diberi perlakuan simetidin dosis 3,6 mg/200gBB, kelompok perlakuan I yaitu hewan uji diberi perlakuan simetidin 3,6 mg/200gBB dan jus pepaya dosis 1 (4,5 g/200gBB) serta kelompok perlakuan 2 dimana hewan uji diberi perlakuan simetidin dan jus pepaya dosis 2 (9 g/200gBB)
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