Abstract
Momordica charantia L. contain alkaloid, flavonoid, phenolic, tannin and saponin compounds which can protect the gastric mucosa. This study aims to determine the effect of giving the ethanol extract of bitter melon leaves (Momordica charantia L.) on the protective activity of the gastric mucosa in aspirin-induced male white rats. Momordica charantia L maceration using 70% ethanol as a solvent. The gastric mucosal protective activity test used 15 male white rats which were divided into 5 groups. The treatments were given orally for 3 days including: the positive control group was given 0.5% Na-CMC + aspirin 600 mg/kgBB, the comparison control group was given sucralfate suspension 360 mg/kgBB + aspirin 600 mg/kgBB, the test dose group 1 was given Pare leaf ethanol extract 100 mg/kgBB + aspirin 600 mg/kgBB, group 2 test dose was given ethanol extract of bitter melon leaves 200 mg/kgBB + aspirin 600 mg/kgBB and group 3 test dose was given ethanol extract of bitter melon leaves 400 mg/kgBB + aspirin 600 mg/kgBB. On day 3, the mice were dissected after 4 hours of aspirin administration, observation and the percentage of gastric mucosal protection in the rats was calculated. Data were analyzed statistically with one-way ANOVA test followed by Duncan's test. The bitter melon leaf extract had a significant effect (p <0.05) on the protection of the gastric mucosa. The highest percentage of protection was shown by the dose of 400 mg / kgBW at 62.48%.
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