Pengaruh Ekstrak Daun dan Buah Ketapang Terhadap Malondialdehida Pankreas Rattus norvegicus Jantan dengan Hiperglikemia yang Diinduksi Aloksan dan Pakan Tinggi Lemak

Abstract

<pre>Diabetes mellitus is a chronic disease caused by high levels of blood glucose. A high-fat diet can cause hyperglycemia .Hyperglycemia will cause the formation of free radicals which can damage cells. Aloksan is a chemical that can damage beta cells, resulting in decreased insulin production. Ketapang (<em>Terminalia catappa</em>) is a plant that can be used because of its antioxidant content. The administration of ketapang extract (<em>Terminalia catappa</em>) is thought to reduce levels of malondialdehyde. Malondialdehyde is a biomarker for the occurrence of lipid peroxidation in the body caused by an increase in free radicals due to the occurrence of oxidative stress.</pre><p> This study used Wistar rats divided into 4 groups. Three groups will be given high-fat diet for 7 days followed by induced alloxan at a dose of 90 mg / kgBW to increase blood glucose levels and pancreatic malondialdehyde levels. Then 2 groups will be given treatment for 14 days. The first treatment group was given Ketapang extract with a dose of 600 mg / kgBW and the second treatment group which was given glibenclamide using a dose of 0.09 mg / kgBW.</p><pre> The results showed that there was a significant decrease in pancreatic malondialdehyde in Wistar rats induced by glibenclamide (p = 0.016). In the group induced by ketapang leaf and fruit extract (Terminalia catappa) there was a decrease in malondialdehyde levels but was not significant (p = 0.916).</pre><p> Conclusions, this study indicated that the administration of ketapang leaf and fruit (<em>Terminalia catappa</em>) extract were able to reduce the levels of pancreatic malondialdehyde given a high-fat diet and induced by alloxan.</p><p> </p>