Abstract
Objective. The aim of this study was to compare buccal and vaginal mucosa with respect to their permeability to a potent carcinogen, benzo[a]pyrene. Study design. Six clinically healthy vaginal mucosa specimens (mean patient age ± standard deviation, 52 ± 13.4 years; age range, 37-69 years) and 6 buccal mucosa specimens (from 5 male patients and 1 female patient: mean patient age ± standard deviation, 32 ± 5.2 years; age range, 24-39 years) were obtained during surgery. In vitro flux rates of benzo[a]pyrene across specimens were determined through use of a flow-through diffusion apparatus. Analysis of variance, a Duncan multiple range test, and an unpaired t test were used to determine steady state kinetics and flux differences over time intervals. Results. No statistically significant differences were observed between the overall mean flux values of benzo[a]pyrene across the 2 kinds of mucosa. Conclusions. The findings further support the hypothesis that human vaginal mucosa can be used as a model for buccal mucosa in studies of permeability to various chemical compounds. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999;87:452-5)
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
