Abstract
(Abstracted from Nat Med 2023;29:1692–1699) Premature ovarian insufficiency (POI), defined as the loss of ovarian activity and permanent cessation of menstruation occurring before age 40 years, affects 1% of women and is a leading cause of infertility. Up to 90% of POI cases are idiopathic, with up to 30% of those having some familial association, suggesting a genetic basis.
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