Penehyclidine hydrochloride and organ protection during cardiopulmonary bypass

Abstract

Background Penehyclidine hydrochloride (PHC),which is derived from hyoscyamine is a new anticholinergic drug,has both antimuscarinic and antinicotinic activities and retains potent central and peripheral anticholinergic activities.Clinical data showed that PHC had good curative effect for the pesticides poison of organic phosphorus and soman poisoning,asthma and chronic obstructive pulmonary disease,septic shock,the diseases of gastrointestinal tract and drug addiction,et al.Additionally,recent studies have suggested that PHC has protective effects of hepatic,renal and lung injury and brain ischemia/reperfusion injury (I/RI).Objective The protective effect of PHC on organs during cardiopulmonary bypass (CPB) is briefly reviewed.Content The pharmacological actions of PHC,and effects on organs during CPB and the mechanism of its action are discussed.Trend Further studies of PHC for prevention of organ injury during CPB in patients with open-heart surgery are needed. Key words: Penehyclidine hydrochloride; Organ protection; Cardiopulmonary bypass