Abstract
Pemphigus vulgaris is a bullous autoimmune disease resulting from loss of adhesion between epithelial cells by deposition of autoantibodies. In case of oral and systemic involvement that affects the quality of life, it is essential that there is interaction of a diversified working group for diagnosis and management. A 42-year-old male presented with bullous extensive lesions in the mouth and body that have progressed to painful squamous ulcers. Under clinical suspicion of erythema multiforme or pemphigus vulgaris, the incisional biopsy of skin was realized. Anatomopathologic examination showed areas of acantholysis, intraepithelial cleft with acantholytic cells, basal layer adhered to basement membrane, and intense chronic inflammatory infiltrating. Paraneoplastic syndrome was investigated and negative. Considering the final diagnosis of pemphigus vulgaris, the patient was referred for management and follow-up with a doctor and psychologist who started treatment with immunosuppressants and pharmacologic and psychological therapy to reduce the pain and damage caused by the clinical condition.
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