PEMPHIGUS VULGARIS AND MUCOUS MEMBRANE PEMPHIGOID: CLINICAL CHARACTERISTICS AND TREATMENT—STUDY COHORT

Abstract

Objective: To compare clinical manifestations and outcome of applied treatments of pemphigus vulgaris (PV) and mucous membrane pemphigoid (MMP). Study Design: Retrospective cohort study through the analysis of records of a stomatology service for 33 years. Demographic data, comorbidities, medications, symptoms, clinical, and histopathological description of the lesions, diagnostic hypothesis, final diagnosis, extraoral manifestations, treatment, and follow-up were collected. Descriptive analysis was performed. Results: 19 cases of MMP and 6 of PV. The female sex was more found in MMP (84%) and in the PV it was male (67%). The mean age was 56.94 years in MMP and 49.5 years in PV. The first consultation occurred in about 6 months for MMP and 2 months for PV with pain complaints present in more than 60% of all cases. The most frequent lesions were desquamative gingivitis in MMP (63%) and non-gingival ulcers in PV (67%). Treatment with minimal therapy was effective in all cases of MMP, but 1 case of PV required adjuvant therapy due to worsening. Conclusions: Individuals with PV presented more exacerbated oral alterations, and may require more careful treatment compared to MMP. Objective: To compare clinical manifestations and outcome of applied treatments of pemphigus vulgaris (PV) and mucous membrane pemphigoid (MMP). Study Design: Retrospective cohort study through the analysis of records of a stomatology service for 33 years. Demographic data, comorbidities, medications, symptoms, clinical, and histopathological description of the lesions, diagnostic hypothesis, final diagnosis, extraoral manifestations, treatment, and follow-up were collected. Descriptive analysis was performed. Results: 19 cases of MMP and 6 of PV. The female sex was more found in MMP (84%) and in the PV it was male (67%). The mean age was 56.94 years in MMP and 49.5 years in PV. The first consultation occurred in about 6 months for MMP and 2 months for PV with pain complaints present in more than 60% of all cases. The most frequent lesions were desquamative gingivitis in MMP (63%) and non-gingival ulcers in PV (67%). Treatment with minimal therapy was effective in all cases of MMP, but 1 case of PV required adjuvant therapy due to worsening. Conclusions: Individuals with PV presented more exacerbated oral alterations, and may require more careful treatment compared to MMP.