Abstract
AbstractPemphigus vulgaris is chronic bullous disease that manifests as bullae and erosions of skin and mucosas, with intraepidermal suprabasal cleft formation seen in the histological examination. It has a rare variant called pemphigus vegetans, where vesicles and bullae are replaced by pustular, verrucous and hyperpigmented lesions, mainly in skin folds. The treatment is similar to that for classic pemphigus vulgaris. The authors present an exuberant case of pemphigus vegetans, covering the nose and chest exclusively, without oral or flexural lesions.
Highlights
Pemphigus vulgaris is a chronic bullous dermatosis, characterized by bullae and erosions of skin and mucosas, caused by IgG autoantibodies against desmosomal glycoproteins Desmoglein 1 (Dsg 1) and 3 (Dsg 3), present on the surface of basal keratinocytes, resulting in loss of cell adhesion and the formation of intraepidermal cleft.[1,2,3]In PV, vesiculobullous lesions rupture leaving erosions and ulcers, mainly in oral mucosa.[4]
Pemphigus vegetans with isolated involvement of the nose and chest: rare variant of pemphigus vulgaris basophilic degeneration of collagen (Figure 3). These findings were compatible with pemphigus vulgaris
Originally described by Neumann in 1876, Pemphigus vegetans (PVeg) is a rare variant of PV, with two known subtypes: Neumann and Hallopeau.[2,7]
Summary
Pemphigus vegetans with isolated involvement of the nose and chest: rare variant of pemphigus vulgaris*. Raisa Ilena Caranhas Feitoza[1], Mônica Santos[1,2], Maria da Conceição Almeida Schettini[3], Silvana de Albuquerque Damasceno Ferreira[4]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
