Abstract
Patients with mucosal pemphigus vulgaris (PV), often develop atypical mucosal vesicles and erosions due to herpes simplex virus (HSV) infection. Notably, HSV infections trigger acantholysis. We aimed to examine the HSV effects on blistering mechanisms of PV. Firstly, we evaluated the additive effect of HSV infection to PV-IgG induced acantholysis and actin cytoskeleton reorganization. Cultured cell sheets of keratinocytes were incubated with 0.1mg/ml of anti-desmoglein (Dsg) 3 antibodies, which were PV-IgG and AK23 monoclonal antibody, for 24hours.
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