Abstract
BackgroundTo evaluate the efficacy of pelvic plexus block (PPB) in relief pain during transperineal template-guided prostate biopsy (TTPB), compared with conventional periprostatic nerve block (PNB).MethodsFrom July 2016 to August 2017, 245 patients who were performed TTPB in Clinical Medical College of Yangzhou University were recruited. The patients were randomized into three groups using a random number table. Group-1 received prostate capsule local anesthesia with 22 ml of 1% lidocaine. Group-2 additionally received PNB on the basis of Group-1. To perform PNB, 5 ml 1% lidocaine was injected into the region of prostatic neurovascular bundle situated in the angle of prostate-bladder-seminal vesicle. Group-3 received prostate capsule local anesthesia plus PPB (5 ml of 1% lidocaine injection into the pelvic plexus which located on lateral to the bilateral seminal vesicle apex). The patients’ pain and satisfaction were evaluated by visual analogue scale and visual numerical scale, respectively.ResultsThe age, total prostate volume, PSA and the number of cores were comparable among the three groups. The visual analog scale scores of group-3 were significantly lower than group-2 during biopsy (P = 0.003). Conversely, the visual numeric scale scores were higher in group-3 (P = 0.039). Both the group-2 and group-3 outperformed the group-1 in alleviating pain and had a higher quantification of satisfaction. There were no significant differences in the pain scores or the satisfaction scores at 30 min after the procedure among the three groups.ConclusionsThe analgesic efficacy of PPB guided by Doppler ultrasound in TTPB was better than that of PNB and both were superior to no nerve block.Trial registrationChiCTR-IOR-17013533, 01/06/2016.
Highlights
To evaluate the efficacy of pelvic plexus block (PPB) in relief pain during transperineal templateguided prostate biopsy (TTPB), compared with conventional periprostatic nerve block (PNB)
PNB is regarded as the “golden standard” of analgesia during prostate biopsy [7,8,9,10]
In 1996, Nash et al [11] were the first to introduce PNB, and found that it can relieve the pain during transrectal ultrasound (TRUS) -guided prostate biopsy
Summary
To evaluate the efficacy of pelvic plexus block (PPB) in relief pain during transperineal templateguided prostate biopsy (TTPB), compared with conventional periprostatic nerve block (PNB). Transperineal templateguided prostate biopsy (TTPB) is one of most effective procedures for detection of prostate cancer [2, 3]. Compared with the transrectal biopsy, transperineal route may cause more pain [4]. Effective anesthesia is a important precondition for successful prostate biopsy [6]. Due to the increase in prostate volume may lead to a decrease in prostate cancer detection rate [15]. In order to improve the positive rate, it is necessary to increase the number of needles, which aggravates the pain of patients. Nguyen et al [18] found that apical biopsies were more painful than were biopsies from other areas of the prostate under PNB
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