Pelvic MRI and CT images are interchangeable for measuring peripouch fat

Xian Hua Gao,Erick Remer,Bo Shen,Nan Lan,Hanumant Chouhan,Luca Stocchi

doi:10.1038/s41598-017-12732-6

Xian Hua Gao, Erick Remer + Show 4 more

Open Access

https://doi.org/10.1038/s41598-017-12732-6

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Abstract

A total of 27 pouch patients with inflammatory bowel diseases, who underwent pelvic MRI-DIXON and CT scan within one year, were included. Peripouch fat areas were measured at the middle height level of pouch (AreaM) and the highest level of pouch (AreaH). Our results demonstrated that measurements of perianal fat thickness, AreaM and AreaH based on MRI image were accurate and reproducible (correlation efficiency(r): intraobserver: 0.984–0.991; interobserver: 0.969–0.971; all P < 0.001). Bland-Altman analysis showed that more than 92.593% (25/27) of dots fell within the limits of agreement. We also identified strong agreements between CT and MRI image in measuring perianal fat thickness(r = 0.823, P < 0.001), AreaM (r = 0.773, P < 0.001) and AreaH (r = 0.862, P < 0.001). Interchangeable calculating formula to normalize measurements between CT and MRI images were created: Thickness_CT = 0.610 × Thickness_MRI + 0.853; AreaM_CT = 0.865 × AreaM_MRI + 1.392; AreaH_CT = 0.508 × AreaH_MRI + 15.001. In conclusion, pelvic MRI image is a feasible and reproducible method for quantifying peripouch fat. Pelvic MRI and CT images are interchangeable in retrospective measurements of peripouch fat, which will foster future investigation of the role of mesentery fat in colorectal diseases.

Highlights

Ulcerative colitis (UC) is a lifelong disease arising from an abnormal interaction between genetic, environmental, and immunological factors1
There were no significant differences between the two groups in terms of age at imaging (41(35–57)vs. 42(36–57) y, P = 0.978), time from pouch construction to imaging (4(1–10)vs. 4(1–10) y, P = 0.986), weight at imaging (69.501 ± 16.698vs. 68.576 ± 16.297 Kg, P = 0.838), height at imaging (1.694 ± 0.113 vs. 1.691 ± 0.114 m, P = 0.899) and body mass index (BMI) at imaging (24.155 ± 5.323vs. 23.890 ± 4.754 Kg/m2,P = 0.848) (Table 2)
The measurements of MRI-DIXON-F images were significantly higher than CT images, in terms of perianal fat thickness, AreaM and AreaH (Table 1)

Summary

Introduction

Ulcerative colitis (UC) is a lifelong disease arising from an abnormal interaction between genetic, environmental, and immunological factors. IPAA improves patients’ quality of life, pouch-related complications can occur, including chronic pouchitis, Crohn’s disease (CD) of pouch and pouch fistula. Those pouch-related complications may result in pouch failure, requiring pouch excision, pouch revision or permanent stoma. As a major composition of mesentery, was shown to be associated with pouch complication and pouch failure in our recent study based on MRI imaging (submission under review). Accurate quantification of peripouch fat using existed CT/MRI image is desirable because it could provide us much valuable information without additional cost Both CT and MRI have been reported in measuring abdominal visceral fat with high accuracy and reliability. Fat with pelvic MRI-DIXON-F images, and to explore interchangeability between pelvic MRI and CT imaging for measuring peripouch fat

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