Abstract
"What God has joined, let no man put asunder," or so goes one local version of the marriage vows. Unfortunately, evolution doesn't seem to play by these rules, and, in this issue of Structure , Lin et al. (2008) describe the discovery of a cryptic FHA module with a remarkable ‘split' domain architecture in Pellino-family proteins, with some intriguing implications for understanding their role in Toll and IL-1 receptor signaling.
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