Abstract
Fish feed pellets are usually manufactured by extrusion of a steam-conditioned meal. However, since high temperatures are involved in this process, it is often not suitable for incorporation of drugs. The pharmaceutical industry uses a variety of pelletization techniques to cope with this problem. To the pharmaceutical industry, pellets are spherical particles with a diameter between 0.25 and 1.5 mm. The most popular pharmaceutical pelletization processes nowadays are the layering of drugs onto inert cores and the extrusion-spheronization process. Other processes such as the wet granulation technique in the rotary processor seem to be promising. This wet granulation technique in the rotary processor was used to produce pellets containing a gonadotropin-releasing hormone analogue and penetration enhancers. This pellet formulation was able to induce ovulation in fish.
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