Abstract
Excess uric acid in blood would cause serious health consequences. Extracorporeal blood purification using solid phase adsorbents is considered as the most promising technique for uric acid removal for patients with nephropathy. In this work, PEI-coated Fe3O4 NPs have been synthesized to be a fast and segregative remover of uric acid. They present a fast and efficient adsorption behavior. Meanwhile, PEI-coated Fe3O4 NPs are magnetic separable and biocompatible. Therefore, PEI-coated Fe3O4 NPs hold a great potential in uric acid removal both in vitro and in vivo.
Highlights
Uric acid is the final product of purine nucleotide catabolism in human body
While, when the concentration of uric acid in serum is over 416 μmol/L for men and 357 μmol/L for women, it is can be diagnosed as hyperuricemia [1]
Patients with nephropathy who suffer from renal failure or renal insufficiency are difficulty in uric acid excretion
Summary
Uric acid is the final product of purine nucleotide catabolism in human body. For healthy people, the production of uric acid is in a dynamic balance. Some adsorbents such as mesoporous silica [7], polyethyleneimine (PEI)/SiO2 particles [8], activated carbon microspheres [9, 10], polymer granules [11], and hydroxyapatite have been tested for their potential application to remove the excess uric acid [12]. Their adsorption efficiencies are proved to be high, those adsorbents are weak in long adsorption time. We have employed Fe3O4 NPs as the core and PEI as the surface to fabricate the novel uric acid adsorbents for fast and segregative removal. Their adsorption efficiency and hemocompatibility have been investigated in this work
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