Abstract
Pegylated Interferon and Ribavirin Treatment for Hepatitis C Virus Infection
Highlights
The prediction of response to interferon-based therapy is an important issue for patients considering embarking on a course of therapy, and providers of care continue to improve their ability to predict success in individual patients by taking into account baseline host (age, race, gender, histology, body weight, insulin resistance, and IL28B genotype) and viral factors
The sustained virologic response (SVR) rate increased from 8%–9% with interferon monotherapy to 30% in genotype 1 patients with the addition of ribavirin, and to 40%–50% with the transition to peginterferon plus ribavirin
As noted in several papers in this special issue, we are on the threshold of increasing the SVR rate in 2011 up to 65%–75% with the addition of a protease inhibitor to the standard of care with peginterferon plus ribavirin
Summary
The prediction of response to interferon-based therapy is an important issue for patients considering embarking on a course of therapy, and providers of care continue to improve their ability to predict success in individual patients by taking into account baseline host (age, race, gender, histology (stage of fibrosis and presence or absence of steatosis), body weight, insulin resistance, and IL28B genotype) and viral factors (genotype and HCV RNA level). Pegylated Interferon and Ribavirin Treatment for Hepatitis C Virus Infection
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