Abstract
Thermosensitive and pegylated polyion complex (PIC) micelles were formed by coassembly of oppositely and permanently charged poly(sodium 2-acrylamido-2-methylpropanesulfonate)-block-poly(N-isopropylacrylamide), PAMPS-b-PNIPAAM, and poly[(3-acrylamidopropyl)-trimethylammonium chloride]-block-poly(ethylene oxide), PAMPTMA-b-PEO, block copolymers under stoichiometric charge neutralization conditions and polyelectrolyte chain length matching. PAMPTMA-b-PEO block copolymers with different block lengths were prepared for the first time by atom transfer radical polymerization (ATRP) using a PEO macroinitiator. PIC micelles were characterized by 1H NMR, static light scattering (SLS), dynamic light scattering (DLS), and transmission electron microscopy (TEM). At room temperature, spherical almost monodisperse PIC micelles, consisting of a mixed PAMPTMA/PAMPS coacervate core and a mixed PEO/PNIPAAM shell, were formed, with size of about 80−110 nm. The PIC micelles completely dissociated to unimers by increasing NaC...
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